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Codeine Phosphate

Original price was: $460.00.Current price is: $60.00.

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Codeine Phosphate online 30mg

Buy Codeine Phosphate online Codeine is an established, familiar and widely used analgesic. It is  a weak opioid, with a potency around one tenth that of morphine (i.e. 60mg of codeine is equivalent to around 6mg of morphine)​[1]​. Codeine is administer in doses of 15–60mg up to four times per day (maximum of 240mg in 24 hours) and confers beneficial analgesic, antitussive and antidiarrhoeal effects​[2,3]​.Buy Codeine Phosphate online

uses codeine phosphate online

Despite its utility and ubiquity, codeine actually has little or no analgesic activity until it is metabolas into morphine​[4,5]​. Consequently, codeine  a pro drug (a compound that is pharmacologically inactive until it is metabolas into an active form by the human body)​[6]​.

codeine phosphate for metabolism

The extent of this metabolism varies however: individuals with differing CYP2D6 enzyme activity may derive differing effects (and associated adverse effects) from the same dose of codeine. Additional limitations include the potential for drug–drug interactions, and a so-called ‘ceiling effect’ that adversely tips the risk–benefit scale at supratherapeutic dose

Metabolism

Codeine is primarily metabolised by two different pathways (see Figure)​[2]​. In most people, around 80{f1b9f947fd282b349f7a9d1c8bdaea8db7728b3458dd3a7c6c5973c14db79c34} of codeine  conjugate to form codeine-6-glucuronide, which may have weak analgesic activity​[2,7]​. However, typically less than 10{f1b9f947fd282b349f7a9d1c8bdaea8db7728b3458dd3a7c6c5973c14db79c34} of codei

The extent of this metabolism varies however:

individuals with differing CYP2D6 enzyme activity may derive differing effects  from the same dose of codeine. Additional limitations include the potential for drug–drug interactions, and ceiling effect’ that adversely tips the risk–benefit scale at supratherapeutic doses​[2,3,6]​. To appreciate the wide-ranging clinical significance of these factors fully, the

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